Homebrew fish works besides not having access to nix commands. Only workaround that does work so far is adding this to my system.nix file, but this seems like a hacky workaround. Like surely there is some way to make this actually work or?

security.sudo.extraConfig = ''
  Defaults secure_path="/Users/${username}/.nix-profile/bin:/etc/profiles/per-user/${username}/bin:/run/current-system/sw/bin:/nix/var/nix/profiles/default/bin:/usr/local/bin:/usr/bin:/bin:/usr/sbin:/sbin"
'';

I ended up doing this, but not sure if there's a better way. I don't think the options you're talking about are the same, this is adding a color tint to the screen:

CustomUserPreferences = {
      # Observed from System Settings after configuring Color Filters.
      "com.apple.mediaaccessibility" = {
        "__Color__-MADisplayFilterCategoryEnabled" = 0;
        "__Color__-MADisplayFilterType" = 16;
        MADisplayFilterSingleColorIntensity = 0.7100822925567627;
      };